New Discoveries at the Scientific Interface

Chemistry + Biochem + Chemical Biology + Engineering + Microbiology

Our research program is inspired by the challenge and importance of elucidating chemical structure and function in complex biological systems. We strive to transform our discoveries into therapeutic strategies and have introduced new antibacterial and anti-virulence compounds to target difficult-to-treat antibiotic-resistant and biofilm-associated infections. We integrate wide-ranging interdisciplinary experimental approaches.  We also leverage our unique spectroscopy expertise and design unconventional approaches using whole-cell and macromolecular solid-state NMR in order to reveal crucial chemistry underlying bacterial phenotypes and drug modes of action.