Variation in the Ratio of Curli and Phosphoethanolamine Cellulose Associated with Biofilm Architecture and Properties. Jeffries J, Thongsomboon W, Visser JA, Enriquez K, Yager D, Cegelski L. Biopolymers (2020) In press (https://onlinelibrary.wiley.com/doi/full/10.1002/bip.23395).

Bicyclohexene-peri-naphthalenes: Scalable Synthesis, Diverse Functionalization, Efficient Polymerization, and Facile Mechanoactivation of their Polymers. Yang J, Horst M, Werby SH, Cegelski L, Burns NZ, Xia Y. JACS (2020) 142, 14619-14626. 

Evaluation of Phosphoethanolamine Cellulose Production among Bacterial Communities using Congo Red Fluorescence. Thongsomboon W, Werby SH, Cegelski L. Journal of Bacteriology (2020) 202, e00030-20. Spotlight: https://jb.asm.org/content/202/13/e00254-20.

Mechanical and Microstructural Insights of Vibrio cholerae and Escherichia coli Dual-species Biofilm at the Air-liquid Interface. Abriat C, Enriquez K, Virgilio N, Cegelski L, Fuller GG, Daigle F, Heuzey M. Colloids and Surfaces B: Biointerfaces (2020) 188, 110786.

A Vancomycin-Arginine Conjugate Inhibits Growth of Carbapenem-resistant E. coli and Targets Cell-Wall Synthesis. Antonoplis A, Zang X, Wegner T, Wender PA*, Cegelski L*. ACS Chemical Biology (2019) 14, 2065-2070.

Unraveling E. coli’s Cloak: Identification of Phosphoethanolamine Cellulose, its Functions, and Applications. Jeffries J, Fuller GG, Cegelski L. Microbiology Insights (2019) https://doi.org/10.1177/1178636119865234. 

Carbon Compositional Analysis of Hydrogel Contact Lenses by Solid-State NMR Spectroscopy. Rabiah NI, Romaniuk JAH, Fuller GG, Scales CW, Cegelski L. Solid-State NMR (2019) 102, 47-52.

Design and Implementation of a Six-Session CURE Module using Biofilms to Explore the Chemistry-Biology Interface. Werby SH and Cegelski L. Journal of Chemical Education (2019) 206, 49-54.

Racing for the Surface: Pathogenesis of Implant Infection and Advanced Antimicrobial Strategies. Shen J, Gurtner GC, Cegelski L, Yang YP. Book chapter in Advances in Antimicrobial and Osteoinductive Studies (2019) In press.

Spectral Comparisons of Mammalian Cells and Intact Organelles by Solid-State NMR. Werby SH and Cegelski L. Journal of Structural Biology (2019) 206, 49-54. [PDF]

Benzoladderene Mechanophores: Synthesis, Polymerization, and Mechanochemical Transformation. Yang J, Horst M, Romaniuk JAH, Jin Z, Cegelski L, Xia Y. Journal of the American Chemical Society (2019) 141, 6479-6483.

Functional Specialization in Vibrio cholerae Diguanylate Cyclases: Distinct Modes of Motility Suppression and c-di-GMP Production. Zamorano-Sánchez D, Xian W, Lee C, Salinas M, Thongsomboon W, Cegelski L, Wong G, Yildiz F. mBio (2019) 10 (2) e00670-19. [PDF]

Respiratory Heterogeneity Shapes Biofilm Formation and Host Colonization in Uropathogenic Escherichia coli. Beebout C, Eberly A, Werby S, Reasoner S, Brannon J, De S, Fitzgerald M, Huggins M, Clayton D, Cegelski L, Hadjifrangiskou M. mBio (2019) 10 (2) e02400-18. [PDF]

Integration of Electron Microscopy and Solid-state NMR Analysis for New Views and Compositional Parameters of Aspergillus fumigatus Biofilms. Reichhardt C, Joubert LM, Clemons KV, Stevens DA, Cegelski L. Medical Mycology (2019) 57, S239-S244. [PDF]

A Dual Function Antibiotic-transporter Conjugate Exhibits Superior Activity in Sterilizing MRSA Biofilms and Killing Persister Cells. Antonoplis A, Zang X, Huttner MA, Chong K, Lee YB, Co JY, Amieva M, Kline KA, Wender PA*, Cegelski L*. JACS (2018) 140, 16140-16150. [PDF] Press: Stanford Report by Nathan Collins.

Phosphoethanolamine Cellulose Enhances Curli-Mediated Adhesion of Uropathogenic Escherichia coli to Bladder Epithelial Cells. Hollenbeck EC, Antonoplis A, Chai C, Thongsomboon W, Fuller GG*, Cegelski L*. PNAS (2018) 115, 10106-10111. [PDF] Press. Stanford Report Article by Ker Than. Nature Reviews Microbiology ("Stronger Together").

Synthesis and Mechanochemical Activation of Ladderene-Norbornene Block Copolymers. Su JK, Feist JD, Yang J, Mercer JAM, Romaniuk JAH, Chen Z, Cegelski L, Burns NZ, and Xia Y. JACS (2018) 140, 12388-12391. [PDF]

The Congo Red Derivative FSB Binds to Curli Amyloid Fibers and Specifically Stains Curliated E. coli. Reichhardt C and Cegelski L. PLoS One (2018) 13(8): e0203226. [PDF]

Peptidoglycan and Teichoic Acid Levels and Alterations in S. aureus by Cell-Wall and Whole-Cell NMR. Romaniuk JAH and Cegelski L. Biochemistry (2018) 57, 3966-3975. [PDF]

Phosphoethanolamine Cellulose: A Naturally Produced Chemically Modified Cellulose. Thongsomboon W, Serra DO, Possling A, Hadjineophytou C, Hengge R*, Cegelski L*. Science (2018) 359, 334-338. [PDF] Perspective by Galperin & Shalaeva.

Press: Nature Microbiology; Stanford Medicine Scope; Science News; Phys.org news; Nature highlight 

REDOR NMR Reveals Multiple Conformers for a Protein Kinase C Ligand in a Membrane Environment. Yang H, Staveness D, Ryckbosch SM, Axtman, AD, Loy, BA, Barnes AB, Pande VS, Schaefer J*, Wender PA*, Cegelski L*. ACS Central Science (2018) 4, 89-96. [PDF]

Whole-Cell Detection of C-P Bonds in Bacteria. Bartlett C, Bansal S, Burnett A, Suits M, Schaefer J, Cegelski L*, Horsman G*, Weadge J*. Biochemistry (2017) 56, 5870–5873. [PDF]

Whole Ribosome NMR: Dipolar Couplings and Contributions to Whole Cells. Nygaard R, Romaniuk JAH, Rice DM, Cegelski L*. Journal of Physical Chemistry B (2017) 121, 9331–9335. [PDF]

Pseudomonas Phage Inhibition of Candida albicans. Nazik H, Joubert LM, Secor PR, Sweere JM, Bollyky PL, Sass G, Cegelski L, Stevens DA*. Microbiology (2017) 163: 1568-1577. [PDF]

Mechanochemical unzipping of insulating polyladderene to semiconducting polyacetylene Chen Z, Mercer JAM, Zhu X, Romaniuk JAH, Pfattner R, Cegelski L, Martinez TJ*, Burns NZ*, Xia Y*. Science (2017) 357, 475–479. [PDF]

Disentangling Nanonets: Human a-Defensin 6 Targets Candida albicans Virulence. Cegelski L. Biochemistry (2017) 56, 1027-1028.   [PDF]

Visualization of Aspergillus fumigatus Biofilms with Scanning Electron Microscopy and Variable Pressure-Scanning Electron Microscopy: a Comparison of Processing Techniques. Joubert L, Ferreira JAG, Stevens DA, Nazik H, McDonald KL, Cegelski L. Journal of Microbiological Methods (2017) 132, 46-55.  [PDF]

Influence of the Amyloid Dye Congo Red on Curli, Cellulose, and the Extracellular Matrix in E. coli during Growth and Matrix Purification. Reichhardt C, McCrate OA, Zhou X, Lee J, Thongsomboon W, Cegelski L. Analytical and Bioanalytical Chemistry (2016) 408, 7709-7717.  [PDF]

Fungal Biofilm Composition and Opportunities in Drug Discovery. Reichhardt C, Stevens DA, Cegelski L. Future Medicinal Chemistry (2016) 8, 1455-1468.  [PDF]

Mechanical Behavior of a Bacillus subtilis Pellicle. Hollenbeck E, Douarche C, Allain J, Roger P, Regeard C, Cegelski L, Fuller GG, Respaud E. Journal of Physical Chemistry B (2016) 120, 6080-6088.  [PDF]

Congo Red Interactions with Curli-Producing E. coli and Native Curli Amyloid Fibers. Reichhardt C, Jacobson AN, Maher MC, Uang J, McCrate OA, Eckart M, Cegelski L. PLoS One (2015) 10, e0140388.  [PDF]

Frequency-Selective REDOR and Spin-Diffusion Relays in Uniformly Labeled Whole Cells. Rice DM, Romaniuk JAH, Cegelski L. Solid-State Nuclear Magnetic Resonance (2015) 72, 132-139.  [PDF]

Cell-Based High-Throughput Screening Identifies Rifapentine as an Inhibitor of Amyloid and Biofilm Formation in E. coli. Maher MC, Lim JY, Gunawan C, Cegelski L. ACS Infectious Diseases (2015) 1, 10, 460-468.  [PDF]

Bacterial Cell Wall Composition and the Influence of Antibiotics by Cell-Wall and Whole-Cell NMR. Romaniuk JAH and Cegelski L. Philosophical Transactions of the Royal Society B (2015) 370, 20150024.   [PDF]

Cyclic-di-GMP Regulates Motile to Sessile Transition by Modulating MshA Pili Biogenesis and Near-Surface Motility Behavior in Vibrio cholerae. Jones C, Utada A, Davis KR, Thongsomboon W, Sanchez DZ, Banakar V, Cegelski L, Wong GCL, Yildiz FH. PLoS Pathogens (2015) 11, e1005068.  [PDF]

Analysis of the Aspergillus fumigatus Biofilm Extracellular Matrix by Solid-State Nuclear Magnetic Resonance Spectroscopy. Reichhardt C, Ferreira JAG, Joubert L, Clemons KV, Stevens DA, Cegelski L. Eukaryotic Cell (2015) 14, 1064-1072.  [PDF]

Spectral Snapshots of Bacterial Cell-Wall Composition and the Influence of Antibiotics by Whole-Cell NMR. Nygaard R, Romaniuk JAH, Rice DM, Cegelski L. Biophysical Journal (2015) 108, 1380-1389. [PDF]

Bottom-Up and Top-Down Solid-State NMR Approaches for Bacterial Biofilm Matrix Composition. Cegelski L. Journal of Magnetic Resonance (2015) 253, 91-97. [PDF]

Toward a Biorelevant Structure of Protein Kinase C Bound Modulators: Design, Synthesis, and Evaluation of Labeled Bryostatin Analogues for Analysis with Rotational Echo Double Resonance NMR Spectroscopy. Loy B, Lesser A, Staveness D, Billingsley K, Cegelski L, Wender P. JACS (2015) 137, 3678-3685. [PDF]

Characterization of the Vibrio cholerae Extracellular Matrix: A Top-Down Solid-State NMR Approach. Reichhardt C, Fong JCN, Yildiz FH, Cegelski L. Biochimica et Biophysica Acta (2015) 1848, 378-383. [PDF]

NMR Spectroscopy for Atomistic Views of Biomembranes and Cell Surfaces. Cegelski L and Weliky DP. Biochimica et Biophysica Acta (2015) 1848, 201-202. Special Issue Editorial. [PDF]

Molecular Determinants of Mechanical Properties of V. cholerae Biofilms at the Air-Liquid Interface. Hollenbeck E, Fong JCN, Lim JY, Yildiz FH, Fuller GG, Cegelski L. From the cover. Biophysical Journal (2014) 107, 2245-2252. [PDF]

Putative Hydrogen Bond to Tyrosine M208 in Photosynthetic Reaction Centers from Rhodobacter capsulatus Significantly Slows Primary Charge Separation. Saggu M, Carter B, Zhou X, Faries K, Cegelski L, Holten D, Boxer SG, Kirmaier C. Journal of Physical Chemistry B (2014) 118, 6721-6732. [PDF]

Solid-State NMR for Bacterial Biofilms. Reichhardt C and Cegelski L. From the cover. Molecular Physics ( 2014) 112, 887-894. [PDF]

Community Behavior and Amyloid-associated Phenotypes among a Panel of Uropathogenic E. coli. Lim JY, Pinkner JS, Cegelski L. Biochemical and Biophysical Research Communications (2014) 443, 345-350. [PDF]

REDOR NMR for Drug Discovery. Cegelski L. Bioorganic & Medicinal Chemistry Letters (2013) 23, 5767-5775. Dedicated to Prof. Jacob Schaefer in celebration of his 75th Birthday and 25 years of REDOR. [PDF]

Sum of the Parts: Composition and Architecture of the Bacterial Extracellular Matrix. McCrate O, Zhou X, Reichhardt C, Cegelski L. Journal of Molecular Biology (2013). [PDF]

Disruption of E. coli Amyloid-Integrated Biofilm Formation at the Air-Liquid Interface by a Polysorbate Surfactant. Wu C, Lim JY, Fuller GG, Cegelski L. Langmuir (2013) 29, 920–926. [PDF]

Curcumin as an Amyloid-Indicator Dye in E. coli. McCrate OA, Zhou X, Cegelski L. Chemical Communications (2013) 49, 4193-4195. [PDF]

Nutrient-Dependent Structural Changes in S. aureus Peptidoglycan Revealed by Solid-State NMR Spectroscopy. Zhou X and Cegelski L. Biochemistry (2012) 51, 8143-8154. [PDF]

Quantitative Analysis of Amyloid-Integrated Biofilms Formed by Uropathogenic E. coli at the Air-Liquid Interface. Wu C, Lim JY, Fuller GG, Cegelski L. Biophysical Journal (2012) 103, 464-471. [PDF]

DMSO and Ethanol Elicit Increased Amyloid Biogenesis and Amyloid-Integrated Biofilm Formation in E. coli. Lim JY, May JM, Cegelski L. Journal of Applied and Environmental Microbiology (2012) 78, 3369-3378. [PDF]

REDOR Applications in Biology: an Overview. Toke O and Cegelski L. In Solid-State NMR Studies of Biopolymers (2010). McDermott, AE and Polenova, T (eds). John Wiley & Sons Ltd, Chichester, UK, pp 473-490. [PDF]

 ------ Cegelski Graduate School and Postdoc Publications ------

Plant Cell-Wall Cross-Links by REDOR NMR Spectroscopy. Cegelski L, O’Connor RD, Stueber D, Singh M, Poliks B, Schaefer J. Journal of the American Chemical Society (2010) 132:16052-7. [PDF]

Small-Molecule Inhibitors Target E. coli Amyloid Biogenesis and Biofilm Formation. Cegelski L, Pinkner JS, Hammer ND, Cusumano CK, Hung CS, Chorell E, Åberg V, Walker JN, Seed PC, Almqvist F, Chapman MR, Hultgren SJ. Nature Chemical Biology (2009) 5, 913-919. [PDF]

Microbial Adhesion. Cegelski L, Smith CL, Hultgren SJ. In The Encyclopedia of Microbiology, ed. Schaechter, M. (2009), 1-10. [PDF]

Morphological Plasticity as a Bacterial Survival Strategy. Justice SJ, Hunstad DH, Cegelski L, Hultgren SJ.Nature Reviews Microbiology (2008) 6, 162-168. [PDF]

The Biology and Future Prospects of Anti-Virulence Therapies. Cegelski L, Marshall GR, Eldridge GR, Hultgren SJ. Nature Reviews Microbiology (2008) 6, 17-27. [PDF]

Oritavancin Exhibits Dual Mode of Action to Inhibit S. aureus Peptidoglycan Biosynthesis. Kim SJ, Cegelski L, Stueber D, Singh M, Dietrich E, Tanaka KS, Parr TR, Farand AR, Schaefer J. Journal of Molecular Biology (2008) 377, 281-293. [PDF]

REDOR NMR Distance Measurements for the Tubulin-Bound Paclitaxel Conformation. Paik Y, Yang C, Metaferia B, Tang S, Bane S, Ravindra R, Shanker N, Alcaraz AA, Johnson SA, Schaefer J, O’Connor RD, Cegelski L, Snyder JP, Kingston DGI. Journal of the American Chemical Society (2007) 129, 361-370. [PDF]

Structures of Staphylococcus aureus Cell-Wall Complexes with Vancomycin, Eremomycin, and Oritavancin Analogues by 13C{19F} and 15N{19F} Rotational-Echo Double Resonance. Kim SJ, Cegelski L, Preobrazhenskaya MN, Schaefer J. Biochemistry (2006) 45, 5235-5250. [PDF]

Conformational and Quantitative Characterization of Oritavancin–Peptidoglycan Complexes in Whole Cells of Staphylococcus aureus by in vivo 13C and 15N Labeling. Cegelski L, Steuber D, Mehta AK, Kulp DW, Axelsen PH, Schaefer J. Journal of Molecular Biology (2006) 357, 1253-1262. [PDF]

Peptide Antibiotics in Action: Investigation of Polypeptide Chains in Insoluble Environments by REDOR. Toke O, Cegelski L, Schaefer J. Biochimica et Biophysica Acta (2006) 1758, 1314-1329. [PDF]

LRP6 Holds the Key for the Entry of Anthrax Toxin. Bann JG, Cegelski L, Hultgren SJ. Cell (2006) 124, 3-5. [PDF]

Photorespiration in Intact Leaves by in vivo 13CO2 Labeling. Cegelski L and Schaefer J. From the cover. Journal of Magnetic Resonance (2006) 178, 1-10. [PDF]

Glycine Metabolism in Intact Leaves by in vivo 13CO2 and 15N Labeling. Cegelski L and Schaefer J. Journal of Biological Chemistry (2005) 280, 39238-39245. [PDF]

Mapping the Locations of Estradiol and Potent Neuroprotective Analogues in Phospholipid Bilayers by REDOR. Cegelski L, Rice CV, O’Connor RD, Caruano AL, Tochtrop GP, Cai ZY, Covey DF, Schaefer J. Drug Development Research (2005) 66, 93-102. [PDF]

REDOR with a Relative Full-echo Reference. Mehta AK, Cegelski L, O’Connor RD, Schaefer J. Journal of Magnetic Resonance (2003) 163, 182-187. [PDF]

REDOR Characterization of the Effects of Vancomycin on Cell Wall Synthesis in S. aureus. Cegelski L, Hing AW, Kim SJ, Studelska DR, O’Connor RD, Mehta AK, Schaefer J. Biochemistry (2002) 41, 13053-13058. [PDF]

REDOR Characterization of Vancomycin Binding Sites in S. aureus. Kim SJ, Cegelski L, Studelska DR, O’Connor RD, Mehta AK, Schaefer J. Biochemistry (2002) 41, 6967-6977. [PDF]

Conformation of Microtubule-Bound Paclitaxel Determined by Fluorescence Spectroscopy and REDOR NMR. Li Y, Poliks B, Cegelski L, Poliks M, Gryczynski Z, Piszczek G, Jagtap PG, Studelska DR, Kingston DGI, Schaefer J, Bane S. Biochemistry (2000) 39, 281-291. [PDF]